Sedating chemical chloroform Sexchat with normal people
The term "pharmaceutically acceptable salts" refers to salts prepared from pharmaceutically acceptable non-toxic bases including inorganic bases and organic bases.Salts derived from inorganic bases include aluminum, ammonium, calcium, copper, ferric, ferrous, lithium, magnesium, manganic salts, manganous, potassium, sodium, zinc, and the like.
The second form of cyclooxygenase, COX-2, is rapidly and readily inducible by a number of agents including mitogens, endotoxin, hormones, cytokines and growth factors. The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I.
John Vane, "Towards a better aspirin" in Nature, Vol. When Ar is di-substituted phenyl it is particularly apt that one of the substituents is hydrogen or fluorine and the second is hydrogen, fluorine, chlorine, methyl, methoxyl or trifluoromethyl.
Another preferred sub-genus of formula I is that wherein R is chloro, wherein there is one group X independently selected from the group consisting of (a) hydrogen, (b) F or Cl, (c) methyl, (d) ethyl.
In another aspect the invention also encompasses a method of treating cyclooxygenase mediated diseases advantageously treated by an active agent that selectively inhibits COX-2 in preference to COX- 1 comprising: administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula I.
In another aspect the invention also encompasses the use of a compound of formula I or a pharmaceutical composition in the manufacture of a medicament for the treatment of an inflammatory disease susceptable to treatment with an a non-steroidal antiinflammatory agent. The following abbreviations have the indicated meanings: AA=arachidonic acid Ac=acetyl AIBN=2.2 -azobisisobutyronitrile BHT=butylated hydroxytoluene Bn=benzyl CSA=camphor sulfonic acid (racemic) dba=dibenzylideneacetone DMAP=4-(dimethylamino)pyridine DMF=N, N-dimethylformamide DMSO=dimethyl sulfoxide EDTA=ethylenediaminetetraacetic acid ESA=ethane sulfonic acid Et - 2-ethanesulfonic acid!
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As prostaglandins have both physiological and pathological roles, we have concluded that the constitutive enzyme, COX-1, is responsible, in large part, for endogenous basal release of prostaglandins and hence is important in their physiological functions such as the maintenance of gastrointestinal integrity and renal blood flow. ##STR3## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.